阅读书目
阅读清单：相关测试
水迷宫的“亲戚”们。
本站相关测试背后的原始论文。
- Barnes (1979). Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat. Journal of Comparative and Physiological Psychology 93(1):74-104. doi:10.1037/h0077579
巴恩斯在一项有利于使用空间线索的圆形平台任务上比较了老年大鼠和成年大鼠，同时记录了海马突触反应。老年大鼠的空间记忆较差，这篇论文首次介绍了如今被称为巴恩斯迷宫的圆形平台任务。 - Olton & Samuelson (1976). Remembrance of places passed: Spatial memory in rats. Journal of Experimental Psychology: Animal Behavior Processes 2(2):97-116. doi:10.1037/0097-7403.2.2.97
Olton和Samuelson提出了放射臂迷宫，表明大鼠能高效地避免重访已经进入过的臂。这项工作确立了放射臂迷宫作为空间工作记忆测试的地位。 - Walf & Frye (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature Protocols 2(2):322-328. doi:10.1038/nprot.2007.44
Walf和Frye给出了将高架十字迷宫用作啮齿动物焦虑相关行为检测的方案，介绍了装置、流程、指标以及影响结果的因素。 - Spooner et al. (1994). The Atlantis platform: a new design and further developments of Buresova's on-demand platform for the water maze. Learning & Memory 1(3):203-211. doi:10.1101/lm.1.3.203
- Olton & Samuelson (1976). Remembrance of places passed: Spatial memory in rats. Journal of Experimental Psychology: Animal Behavior Processes 2(2):97-116. doi:10.1037/0097-7403.2.2.97 经典
Olton和Samuelson提出了放射臂迷宫，表明大鼠能高效地避免重访已经进入过的臂。这项工作确立了放射臂迷宫作为空间工作记忆测试的地位。 - Barnes (1979). Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat. Journal of Comparative and Physiological Psychology 93(1):74-104. doi:10.1037/h0077579 经典
巴恩斯在一项有利于使用空间线索的圆形平台任务上比较了老年大鼠和成年大鼠，同时记录了海马突触反应。老年大鼠的空间记忆较差，这篇论文首次介绍了如今被称为巴恩斯迷宫的圆形平台任务。 - Pellow et al. (1985). Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods 14(3):149-167. doi:10.1016/0165-0270(85)90031-7 经典
Pellow、Chopin、File和Briley在大鼠中验证了高架十字迷宫，表明进入开放臂的比例和在开放臂停留的时间会对抗焦虑和致焦虑处理产生反应。这是将高架十字迷宫用作焦虑指标的标准参考文献。 - Treit & Fundytus (1988). Thigmotaxis as a test for anxiolytic activity in rats. Pharmacology Biochemistry and Behavior 31(4):959-962. doi:10.1016/0091-3057(88)90413-3 经典
特雷特和丰迪特斯证明，在旷场中测试的大鼠大部分时间待在墙边（趋触性），而抗焦虑药会减少这种倾向。他们提出把趋触性作为检测抗焦虑活性的简单测试。 - Simon et al. (1994). Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behavioural Brain Research 61(1):59-64. doi:10.1016/0166-4328(94)90008-6 经典
西蒙、迪皮伊和科斯唐坦提出，把旷场探索早期趋触性（待在墙边）的程度作为小鼠焦虑的指标。他们用致焦虑药和抗焦虑药验证了这一点，并考察了多巴胺能传递的作用。 - Prut & Belzung (2003). The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European Journal of Pharmacology 463(1-3):3-33. doi:10.1016/s0014-2999(03)01272-x 经典
Prut和Belzung综述了用旷场测量药物对啮齿动物焦虑样行为影响的方法，总结了该测试能检测出哪些类别的药物及其局限性。 - Walf & Frye (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature Protocols 2(2):322-328. doi:10.1038/nprot.2007.44 经典
Walf和Frye给出了将高架十字迷宫用作啮齿动物焦虑相关行为检测的方案，介绍了装置、流程、指标以及影响结果的因素。 - Floresco et al. (1997). Selective Roles for Hippocampal, Prefrontal Cortical, and Ventral Striatal Circuits in Radial-Arm Maze Tasks With or Without a Delay. The Journal of Neuroscience 17(5):1880-1890. doi:10.1523/jneurosci.17-05-01880.1997
- Sunyer et al. (2007). Barnes maze, a useful task to assess spatial reference memory in the mice. Protocol Exchange . doi:10.1038/nprot.2007.390
- Rosenfeld & Ferguson (2014). Barnes Maze Testing Strategies with Small and Large Rodent Models. Journal of Visualized Experiments (84). doi:10.3791/51194
- Seibenhener & Wooten (2015). Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice. Journal of Visualized Experiments (96). doi:10.3791/52434
- Bertolli et al. (2026). Renovating the Barnes maze for mouse models of dementia with STARR FIELD: A 4-day protocol for learning rate, retention, and cognitive flexibility. Methods 251:64-82. doi:10.1016/j.ymeth.2026.04.004