小鼠与大鼠
Roger Morris博士的小鼠水迷宫提示
“由压力/奖励提供的动机与一项困难任务之间的微妙平衡。”
1998年,Roger Morris博士(不要与发明该迷宫的Richard Morris教授混淆)分享了他来之不易的小鼠实验笔记。这些笔记实用、略带幽默,至今仍很有用。我们把它们分成了若干短页面;以下是开头部分(英文原文)。
Mouse / Water maze Hints
12/98. Copyright (C) 1998 RJ Morris & HVS Image.
The following notes are edited from material kindly supplied by Dr. Roger Morris.
Editor's notes:
“a) Rats are natural swimmers and if handled well will cooperate easily in Water Maze. They don't have the option to float or jump - they are solid citizens who just swim for that platform and get onto it.
b) Mice are also good swimmers, and if handled well, will also take part easily. But they are more temperamental, and they do have the option to stop swimming and just float, and to jump. These notes suggest ways to reduce stress, so your mice will feel confident, and cooperate.
”
-Richard Baker
Introduction
The swimming-pool (Morris Water Maze) is a delicate balance of motivation provided by stress/reward, and a difficult task. It is an unnatural for rodents, for whom sight is a minor sense. If the stress is too high, or the reward too slight, the task is not attempted.
原文(英文):Dr Roger J Morris,1998年,附Richard Baker的编者注。Copyright (C) 1998 RJ Morris & HVS Image. 按原样转载,未作改动。Copyright Richard Baker© 2013. All Rights Reserved.
- 平台与水平台上的网、5 mm水深和精确的24 °C。
- 平台停留时间与救援在平台上停留十秒,以及为什么救援就是奖励。
- 适合小鼠的线索按小鼠视角摆放和设计的线索。
- 时间与间隔游泳时长、每天两次或四次试次,以及30分钟间隔。
- 抓取与适应用两天时间相互熟悉,而且不要用香水。
关于追踪体型小、动作快的动物,请参阅HVS Image能做什么。